Structural Basis Underlying Strong Interactions between Ankyrins and Spectrins
نویسندگان
چکیده
منابع مشابه
Ankyrins and Spectrins in Cardiovascular Biology and Disease
Ankyrins are adaptor proteins critical for the expression and targeting of cardiac membrane proteins, signaling molecules, and cytoskeletal elements. Findings in humans and animal models have highlighted the in vivo roles for ankyrins in normal physiology and in cardiovascular disease, most notably in cardiac arrhythmia. For example, human ANK2 loss-of-function variants are associated with a co...
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Ankyrin adaptors together with their spectrin partners coordinate diverse ion channels and cell adhesion molecules within plasma membrane domains and thereby promote physiological activities including fast signaling in the heart and nervous system. Ankyrins specifically bind to numerous membrane targets through their 24 ankyrin repeats (ANK repeats), although the mechanism for the facile and in...
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ژورنال
عنوان ژورنال: Journal of Molecular Biology
سال: 2020
ISSN: 0022-2836
DOI: 10.1016/j.jmb.2020.04.023